Locations allow you to use regular expressions to match parts of the URL. As an example you might want to setup a different profile for requests that have “/images” in them.
Once you have a location for “/images” you can then set your own custom Location rules up in the Servers section. This allows you to cache differently, change expiry times, limit requests per second and much more.
Another example would be a downloads location – you might want to only allow 1 download per user at any time.